电影《千博士驱魔研究所》改编自同名网漫，叙述,阐述,陈述,描写虽然听不到鬼，但凭借鬼般的洞察力解决各种事件的假驱魔师"千博士"（姜栋元 饰）受到从未经历过的强烈附身事件的委托而起始,开端,肇始,启始的故事。
　　《千博士驱魔研究所》由制作了《老手》《Exit》《摩加迪沙》的外柔内刚公司制作，这也是曾担任《分离,离别,离别,分别,分离,别离,分散,分别,离别,分离的决心》《寄生虫》《惟愿从险恶,凶恶,歹毒,恶毒中拯救我》助理导演的金成植的长片处女作。

　　资深刑警崔昌植（孙贤周 饰）新近升职，加上极其器重他的署长跟上层不断美言，崔班长的前途一片光明。谁知正当他春风得意之际，一桩意外突然向他袭来。在和下属饮酒聚餐后，崔昌植乘坐出租归家,返家,还家,归宅，不曾想出租车司机将他拉到荒郊野外。对方似乎知道崔班长干过的所有罪恶勾当，一番激烈搏斗后，对方死于崔班长之手。在此之后，他刻意伪装不在场证明，以图瞒混过关。次日一早，受害者尸体竟然被人用吊车悬挂在江南警察局的对面，由此在社会上引起极大震动，而做贼心虚的崔昌植也感觉受到了前所未有的威胁。
　　隐藏在黑暗之中的对手是谁？他究竟想干什么？

　　电视台主播韩京培（薛景求 饰）的孩子,男孩,少年,男童被绑架了，绑匪（姜东元 饰）打来电话要求1亿韩元的赎金，京培不得讨价还价。京培与妻子智善（金南珠 饰）都十分着急，无奈之下只好报警了，警方很快展开了调查。
　　警方的高科技调查方式对于狡猾的罪犯来说根本起不了作用。唯一有用的证据便是绑匪打来电话时被录下了的嗓音。一把低沉而且毫无感情的嗓音。案情一直没有进展，京培与妻子连孩子,男孩,少年,男童的死活都不知道。于是京培决心,打算,计划,准备自己出面，偷偷向绑匪提出见面的要求。

　　Chan-woo, who has been studying to become a police officer for 5 years, joins his friends for dinner to ask for the money to apply for his exam and ends up getting drunk. He completely blacks out and wakes up not remembering what happened in his next door neighbor's room. Not only that, he finds a bloody corpse in the middle of the room. He hurries back to his room and tries to report the incident but he had forgotten his phone in the other room. But the door is locked and he has to resort to using a rope to swing to the next door room outside the window. Once the phone is recovered, he cannot go back because of a group of cultists who are evangelizing the neighbors in the hallway. He knows it’s the last day to apply for his exam and gets antsy as time is running out.